Kamis (4/11/21) malam WIB:
Flora (2) vs (2) Anorthosis
Almaty (1) vs (2) Qarabag
Jumat (05/11/21) dini hari WIB:
AZ Alkmaar (2) vs (0) CFR Cluj
Gent (1) vs (1) Partizan
LASK (2) vs (0) Alashkert
Lincoln Red Imps (1) vs (4) Slovan Bratislava
Maccabi Tel Aviv (3) vs (0) HJK
Omonia (1) vs (1) Basel
Randers FC (2) vs (2) Jablonec
Zorya (2) vs (0) CSKA Sofia
AS Roma (2) vs (2) Bodo/Glimt
PAOK (1) vs (2) FC Copenhagen
Rennes (1) vs (0) Mura
Slavia Praha (1) vs (0) Maccabi Haifa
Tottenham Hotspur (3) vs (2) Vitesse
Union Berlin (1) vs (2) Feyenoord.
